Brought aboard the project earlier this year, director Scott Cooper has now left Warner Bros.' adaptation of Stephen King's The Stand.
The Wrap reports that he and the studio met with creative differences over how to properly adapt the material.
Cooper, the Crazy Heart helmer whose latest, Out of the Furnace, hits theaters December 6, boarded the project to both direct and rewrite following the departure of the formerly attached Ben Affleck.
Previously adapted as a television miniseries in 1994, "The Stand" tells the story of a full-scale apocalypse, driven by the accidental release of a biological weapon and the ensuing struggle of good versus evil carried out by the world's final survivors.
A replacement for Cooper has not yet been announced, but check back for details as they become available.