Lee most recently directed 2008’s Soul Men and previous credits include The Best Man, Undercover Brother, Roll Bounce and Welcome Home, Roscoe Jenkins.
Lee will also serve as a writer and producer for the film, alongside David Zucker, who wrote and directed the last two Scary Movies.
Scary Movie 5 will shoot this summer with a targeted release of January 11, 2013.
(Photo Credit: Nikki Nelson / WENN)