MacFarlane directs, produces and co-writes A Million Ways to Die in the West. He also plays the role of the sheep farmer (Albert) with an all-star cast that includes Charlize Theron, Liam Neeson, Amanda Seyfried, Sarah Silverman, Giovanni Ribisi and Neil Patrick Harris. The filmmaking team behind the hit film Ted - producers Scott Stuber and Jason Clark and co-writers Wellesley Wild and Alec Sulkin - are reuniting with MacFarlane, Universal and MRC for the project, which is described as follows:
After a cowardly sheep farmer backs out of a gunfight, his fickle girlfriend leaves him for another man. When a mysterious and beautiful woman rides into town, she helps him find his courage and they begin to fall in love. But when her husband, a notorious outlaw, arrives seeking revenge, the farmer must put his newfound courage to the test.