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Based on Ophira Eisenberg's comic memoir “Screw Everyone: How I Slept My Way to Monogamy." In the book, Eisenberg talks about her decade and a half lifestyle of one night stands, meeting and sleeping with many guys and enjoying casual sex until finally settling down with one guy and enjoying the stability of a monogamous relationship. All of it is recounted in a humorous style going back to her time in Calgary, Canada and her first kiss.